2-amino-N,N-diethyl-5-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]benzamide → Ethyl hydrogen (4-{[4-({6-[1-(2,2-difluoro-3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

반응식

NC1C=CC(C2C=NN(CCCO)C=2)=CC=1C(N(CC)CC)=O.[F:24][C:25]([F:73])([CH2:71][OH:72])[CH2:26][N:27]1[CH:31]=[C:30]([C:32]2[N:37]=[C:36]([C:38](=[O:41])[NH:39][CH3:40])[C:35]([NH:42][C:43]3[C:48]([C:49]([F:52])([F:51])[F:50])=[CH:47][N:46]=[C:45]([NH:53][C:54]4[CH:68]=[CH:67][C:57]([CH2:58][P:59](=[O:66])([O:63]CC)[O:60][CH2:61][CH3:62])=[CH:56][C:55]=4[O:69][CH3:70])[N:44]=3)=[CH:34][CH:33]=2)[CH:29]=[N:28]1>>[F:73][C:25]([F:24])([CH2:71][OH:72])[CH2:26][N:27]1[CH:31]=[C:30]([C:32]2[N:37]=[C:36]([C:38](=[O:41])[NH:39][CH3:40])[C:35]([NH:42][C:43]3[C:48]([C:49]([F:52])([F:51])[F:50])=[CH:47][N:46]=[C:45]([NH:53][C:54]4[CH:68]=[CH:67][C:57]([CH2:58][P:59](=[O:63])([OH:66])[O:60][CH2:61][CH3:62])=[CH:56][C:55]=4[O:69][CH3:70])[N:44]=3)=[CH:34][CH:33]=2)[CH:29]=[N:28]1