Imidazole → 2-[5-[2-[Tert-butyl(dimethyl)silyl]oxyethyl]-2-thienyl]acetic acid

HRID 2279959노트

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HRID 2279959 반응식
[OH:1][CH2:2][CH2:3][C:4]1[S:8][C:7]([CH2:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=1.N1C=CN=C1.[Si:18](Cl)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O.O1CCCC1>[Si:18]([O:1][CH2:2][CH2:3][C:4]1[S:8][C:7]([CH2:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=1)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]

참가 물질

8

반응물 4

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 28928tert-Butyldimethylsilyl chlorideHCID 579889872-(5-(2-Hydroxyethyl)thiophen-2-yl)acetic acid

생성물 1

HCID 1236351082-[5-[2-[Tert-butyl(dimethyl)silyl]oxyethyl]-2-thienyl]acetic acid수율 23%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

To a solution of 2-[5-(2-hydroxyethyl)-2-thienyl]acetic acid (1.35 g, 7.26 mmol) and imidazole (1.04 g, 15.25) in N,N-dimethylformamide (18 mL) was added tert-butyldimethylsilyl chloride (2.29 g, 15.25 mmol) over 20 minutes. The resultant solution was stirred at room temperature for one hour. Tetrahydrofuran (18 mL) was then added and reaction solution cooled to 0° C. A solution of potassium carbonate (1.04 g, 7.6 mmol) in water (18 mL) was added and the solution stirred for 20 minutes. The reaction solution was then partitioned between ethyl acetate and brine. The organic phases were combined, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography, eluting with 0-50% ethyl acetate in iso-hexane to give the title compound as a yellow oil (500 mg, 23%).

후처리

  1. customreaction solution
  2. customThe reaction solution was then partitioned between ethyl acetate and brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by silica gel chromatography
  7. washeluting with 0-50% ethyl acetate in iso-hexane

출처 및 근거

ORD 기록
ord-25722c27ca444afea69d06427a5365e9
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133185B2

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