1,3,4-Thiadiazol-2-amine, 5-(trifluoromethyl)- → (2S,4S)-4-fluoro-1-[[N-[4-[N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	1,3,4-Thiadiazol-2-amine, 5-(trifluoromethyl)-	HCID 82634	—
반응물	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
생성물	(2S,4S)-4-fluoro-1-[[N-[4-[N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile	HCID 57756797	16.4%

반응 단계

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-amino-5-trifluoromethyl-1,3,4-thiadiazole (57.5 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (12.0 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07560569B2
출처 데이터셋	uspto-grants-2009_07
ORD ID	ord-03d5e8e266a54f09b223508e52678ca5
출처 메모	uspto-grants-2009_07