돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 228042생성일: 2026년 10월 25일

2-(4-Aminophenyl)benzothiazole → (2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile

https://huagongshe.com/reaction/228042

반응식

참여 물질

역할이름HCID투입량
반응물2-(4-Aminophenyl)benzothiazoleHCID 234475—
반응물(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrileHCID 57634365—
생성물(2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrileHCID 5775676912.7%

반응 단계

In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-(benzothiazol-2-yl)aniline (51.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[4-(benzothiazol-2-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (10.4 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07560569B2
출처 데이터셋uspto-grants-2009_07
ORD IDord-ed64cc21e8e64848adb9b24729f6ac73
출처 메모uspto-grants-2009_07