Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate → (2s,4s)-1-[[n-[4-[n-(5-Ethoxycarbonylmethylthio-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate | HCID 351912 | — |
| 반응물 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 생성물 | (2s,4s)-1-[[n-[4-[n-(5-Ethoxycarbonylmethylthio-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 68843700 | 20.2% |
반응 단계
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and ethyl[(5-amino-1,3,4-thiadiazol-2-yl)thio]acetate (74.6 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(5-ethoxycarbonylmethylthio-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (16.4 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560569B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-4a6c2905117048fb8fb956b1775f2c17 |
| 출처 메모 | uspto-grants-2009_07 |