Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-(4-chloro-3-nitrophenyl)methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Chloro-3-nitroaniline | HCID 12477 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(4-chloro-3-nitrophenyl)methanesulfonamide | HCID 3755760 | 92.2% |
반응 단계
A mixture of 4-chloro-3-nitroaniline (5.0 g, 29 mmol), methanesulfonyl chloride (2.37 mL, 30.4 mmol) and pyridine (5.9 mL, 72.4 mmol) in THF (100 mL) was stirred for 24 h. Poured in 1M HCl (500 mL). The resulting precipitate was filtered and air-dried to provide the title compound as a solid (6.7 g, 92%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09139536B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-ff7cc3558c8a4c9a916f098f2c19f50a |
| 출처 메모 | uspto-grants-2015_09 |