(4'-(Benzyloxy)-2,2',6'-trimethylbiphenyl-3-yl)methanol → 3'-(Hydroxymethyl)-2,2',6-trimethylbiphenyl-4-ol

HRID 2280656노트

반응식

HRID 2280656 반응식
C([O:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][OH:23])[C:17]=2[CH3:24])=[C:11]([CH3:25])[CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:23][CH2:22][C:18]1[C:17]([CH3:24])=[C:16]([C:12]2[C:11]([CH3:25])=[CH:10][C:9]([OH:8])=[CH:14][C:13]=2[CH3:15])[CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 1

HCID 89701782(4'-(Benzyloxy)-2,2',6'-trimethylbiphenyl-3-yl)methanol

생성물 1

HCID 683329993'-(Hydroxymethyl)-2,2',6-trimethylbiphenyl-4-ol수율 92.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

(4′-(Benzyloxy)-2,2′,6′-trimethylbiphenyl-3-yl)methanol 12c (190 mg, 0.57 mmol) was dissolved in 5 mL of methanol, followed by addition of Pd/C (20 mg, 10%) under hydrogen atomosphere. The reaction solution was stirred for 12 hours. The resulting solution was filtered, and the filtrate was concentrated under reduced pressure to obtain the crude title compound 3′-(hydroxymethyl)-2,2′,6-trimethylbiphenyl-4-ol 12d (128 mg) as a yellow solid, which was used directly in the next step without further purification.

후처리

  1. filtrationThe resulting solution was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-844baf1510b544ce904b4cae442b56e6
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139548B2

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