Sodium Acetate → HCID 75600536, 화합물

HRID 2281028노트

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HRID 2281028 반응식
[CH2:1]([N:3]1[C:7](=[S:8])[CH2:6][O:5][C:4]1=[S:9])[CH3:2].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[O:22][C:21]([CH:23]=O)=[CH:20][CH:19]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH2:1]([N:3]1[C:7](=[S:8])[C:6](=[CH:23][C:21]2[O:22][C:18]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][CH3:10])=[CH:19][CH:20]=2)[O:5][C:4]1=[S:9])[CH3:2]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 46749915-(2-Methoxyphenyl)-2-furancarboxaldehydeHCID 86676053HCID 86676053, 화합물

생성물 1

HCID 75600536HCID 75600536, 화합물수율 95%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a mixture of 3-ethyloxazolidine-2,4-dithione 6 (79 mg, 0.49 mmol), 5-(2-methoxyphenyl)-2-furaldehyde 9 (99 mg, 0.49 mmol) and sodium acetate (201 mg, 2.45 mmol) was added acetic acid (5 mL). As more of the desired product was formed, the reaction mixture color turned to a very red solution. The reaction mixture was refluxed overnight, then the excess solvent was removed in vacuo. The residue was diluted with ethyl acetate (100 mL), then washed with water (2×20 mL). The organic layer was dried with brine and MgSO4, then concentrated in vacuo. Flash column chromatography afforded the desired product 2 (M103) in 95% yield (160 mg, purple solid).

출처 및 근거

ORD 기록
ord-bf9f6bc7873a4108a34da8f8d5a4511c
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139575B2

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