Trifluoroacetic acid → (+/-)-4-(3-Methyl-1-((3-methylquinolin-2-yl)amino)butyl)benzoic acid trifluoroacetic acid salt

HRID 2281158노트

반응식

HRID 2281158 반응식
[CH3:1][CH:2]([CH3:30])[CH2:3][CH:4]([C:17]1[CH:29]=[CH:28][C:20]([C:21]([O:23]C(C)(C)C)=[O:22])=[CH:19][CH:18]=1)[NH:5][C:6]1[C:15]([CH3:16])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>ClCCl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH3:1][CH:2]([CH3:30])[CH2:3][CH:4]([C:17]1[CH:18]=[CH:19][C:20]([C:21]([OH:23])=[O:22])=[CH:28][CH:29]=1)[NH:5][C:6]1[C:15]([CH3:16])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71243814Tert-butyl (+/-)-4-(3-methyl-1-((3-methylquinolin-2-yl)amino)butyl)benzoate

생성물 1

HCID 86718841(+/-)-4-(3-Methyl-1-((3-methylquinolin-2-yl)amino)butyl)benzoic acid trifluoroacetic acid salt

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl (+/−)-4-(3-methyl-1-((3-methylquinolin-2-yl)amino)butyl)benzoate (325 mg, 0.803 mmol) in dichloromethane (8.0 mL) was added trifluoroacetic acid (0.62 mL, 8.0 mmol). The solution was stirred at room temperature for 17 hours then concentrated under reduced pressure. Toluene (3 mL) was added, and the solution was again concentrated under reduced pressure to remove excess trifluoroacetic acid to give (+/−)-4-(3-methyl-1-((3-methylquinolin-2-yl)amino)butyl)benzoic acid trifluoroacetic acid salt as a white solid. 1H NMR (400 MHz, CD3OD) δ 8.26 (s, 1 H), 8.06 (d, J=8.4 Hz, 2 H), 7.84 (d, J=7.8 Hz, 1 H), 7.80-7.75 (m, 1 H), 7.75-7.69 (m, 1 H), 7.58 (d, J=8.4 Hz, 2 H), 7.55-7.48 (m, 1 H), 5.50 (dd, J=5.0, 9.5 Hz, 1 H), 2.56 (s, 3 H), 2.24-2.14 (m, 1 H), 1.92-1.75 (m, 2 H), 1.08 (d, J=6.4 Hz, 3 H), 1.05 (d, J=6.2 Hz, 3 H).

후처리

  1. concentrationthen concentrated under reduced pressure
  2. additionToluene (3 mL) was added
  3. concentrationthe solution was again concentrated under reduced pressure
  4. customto remove excess trifluoroacetic acid

출처 및 근거

ORD 기록
ord-dd63d37f736046c7a1611fc021e326e6
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139538B2

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