Chlorosuccinimide → HCID 57990315, 화합물

HRID 2281425노트

반응식

HRID 2281425 반응식
[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.C1C(=O)N([Cl:23])C(=O)C1>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[C:4]([NH:11][CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:5]2[C:10]([Cl:23])=[CH:9][NH:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 57990291HCID 57990291, 화합물

생성물 1

HCID 57990315HCID 57990315, 화합물수율 19.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 2-chloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (102 mg, 0.460 mmol) in CH2Cl2 (5 mL) at room temperature, NCS (68 mg, 0.51 mmol) was added. The mixture was stirred at reflux for 18 h. After being concentrated in vacuo, the residue was purified by HPLC to give 2,5-dichloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (23 mg).

후처리

  1. temperatureat reflux for 18 h
  2. concentrationAfter being concentrated in vacuo
  3. customthe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-cee72021a83640a6bc1bf58c01e54bdd
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139581B2

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