Water → 1-(4-(4-(4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	Chlorotrimethylsilane	HCID 6397	—
반응물	1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one	HCID 736269	—
반응물	2-chloro-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine	HCID 57990275	—
용매	1-Butanol	HCID 263	—
용매	Ethyl Acetate	HCID 8857	—
생성물	1-(4-(4-(4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone	HCID 69023137	48.7%

반응 조건

온도	116 °C

반응 단계

A mixture of 2-chloro-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine (484 mg, 2.43 mmol), 1-(4-(4-aminophenyl)piperazin-1-yl)ethanone (645 mg, 2.95 mmol) and trimethylsilyl chloride (0.500 mL, 3.95 mmol) in nBuOH (10 mL) was heated at 116° C. for 48 h. After cooling down, H2O and EtOAc were added. The organic phase was separated, washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give 1-(4-(4-(4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone as a solid (453 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09139581B2
출처 데이터셋	uspto-grants-2015_09
ORD ID	ord-3a5a9ffb2f4749749d9b38f9ce9ab9e9
출처 메모	uspto-grants-2015_09