4-(Methanesulfonylmethyl)aniline → 1H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine

HRID 2281471노트

반응식

HRID 2281471 반응식
C1([NH:5][C:6]2[C:7]3[CH:31]=[CH:30][NH:29][C:8]=3[N:9]=[C:10]([NH:12]C3C=CC(S(N4CCC(O)CC4)(=O)=O)=CC=3)[N:11]=2)CCC1.CS(CC1C=CC(N)=CC=1)(=O)=O>>[N:9]1[C:8]2[NH:29][CH:30]=[CH:31][C:7]=2[C:6]([NH2:5])=[N:11][C:10]=1[NH2:12]

참가 물질

3

반응물 2

HCID 128439644-(Methanesulfonylmethyl)anilineHCID 444677461-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol

생성물 1

HCID 103518551H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine

실험 절차

According to the general procedure for synthesis of 1-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol, 4-(methylsulfonylmethyl)aniline and 2-Chloro-N-cylclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine gave N4-cyclobutyl-N2-(4-methylsulfonylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine (MS calcd for C18H21N5O2S 371.5. found [MH] 372.1; UV 205.1, 273.6, 304.5 nm).

출처 및 근거

ORD 기록
ord-c456f58d46cc4a449983798cf8a332e8
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139581B2

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