Benzene, 1-(isocyanatomethyl)-2-(trifluoromethoxy)- → 6-(2-Trifluoromethoxy-benzylcarbamoyl)-1,6-diaza-spiro[3.3]heptane-1-carboxylic acid tert-butyl ester
반응식
[C:1]([O:5][C:6]([N:8]1[C:11]2([CH2:14][NH:13][CH2:12]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]([F:29])([F:28])[O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24][N:25]=[C:26]=[O:27]>>[C:1]([O:5][C:6]([N:8]1[C:11]2([CH2:12][N:13]([C:26](=[O:27])[NH:25][CH2:24][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][C:16]([F:29])([F:15])[F:28])[CH2:14]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
3
실험 절차
In analogy to the experimental procedure of example 8) 1,6-diaza-spiro[3.3]heptane-1-carboxylic acid tert-butyl ester instead of 1-benzyl-1,6-diaza-spiro[3.3]heptane was converted using 1-trifluoromethoxy-2-isocyanatomethyl-benzene instead of (3-isocyanato-propyl)-benzene into the title compound which was used directly in the next step without further purification.
출처 및 근거
- ORD 기록
- ord-daed1c6043ae463e86fc4ec9f6f14bd8
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09139593B2
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