4-Hydroxybenzaldehyde → 3-Fluoro-4-(4-formylphenoxy)benzonitrile

HRID 228185노트

반응식

HRID 228185 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1F)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[C:14]#[N:15]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 5872033,4-Difluorobenzonitrile

생성물 1

HCID 534256703-Fluoro-4-(4-formylphenoxy)benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Basic displacement reaction of 4-hydroxy benzaldehyde and 3,4 difluorobenzonitrile using potassium carbonate in anhydrous DMF at reflux temperatures affords the above compound.

후처리

  1. temperatureat reflux temperatures
  2. customaffords the above compound

출처 및 근거

ORD 기록
ord-c02674a61c5f4a8580f06127af50fcf3
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560463B2

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