Sodium Methoxide → HCID 178517415, 화합물
반응식
Cl[C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]3[CH:18]=[CH:17][O:16][N:15]=3)[N:11]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[N:10]=2)[N:3]=1.C[O-:28].[Na+]>CO>[F:8][C:7]1[C:2]([OH:28])=[N:3][C:4]([C:9]2[CH:13]=[C:12]([C:14]3[CH:18]=[CH:17][O:16][N:15]=3)[N:11]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[F:26])[N:10]=2)=[N:5][CH:6]=1참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
To a solution of 3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2fluorobenzyl)-1H-pyrazol-5-yl)isoxazole (Compound 30, 0.040 g, 0.107 mmol) in 1 mL methanol was added sodium methoxide (0.024 ml, 0.107 mmol) as a 25% weight solution. The reaction was stirred at 40° C. until judged complete by LC/MS. Once complete, the reaction mixture was directly concentrated in vacuo, and the resulting crude oil was purified using silica gel chromatography employing a 0-100% ethyl acetate in hexane gradient to afford the desired compound as a white solid in 55% yield.