Lawesson's reagent → HCID 86649596, 화합물

HRID 2282217노트

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HRID 2282217 반응식
[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]([NH2:10])=O)[C:5]([CH3:11])=[N:4]1)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:21])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([N:3]1[CH:7]=[C:6]([C:8](=[S:21])[NH2:10])[C:5]([CH3:11])=[N:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 87949Lawesson's reagentHCID 49949164HCID 49949164, 화합물

생성물 1

HCID 86649596HCID 86649596, 화합물수율 24%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a suspension of 1-ethyl-3-methyl-1H-pyrazole-4-carboxamide (1.7 g, 11 mmol) produced above in toluene (80 mL) was added Lawesson's reagent (7.0 g, 17 mmol), and the mixture was heated under reflux for 1.5 hr. The reaction solution was cooled to room temperature and purified by basic silica gel column chromatography (ethyl acetate/hexane=0/100→20/80) to give the title compound (445 mg, 24%) as a yellow oil.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hr
  3. custompurified by basic silica gel column chromatography (ethyl acetate/hexane=0/100→20/80)

출처 및 근거

ORD 기록
ord-3ce7e0a2721b455e8bfe21c6c2051314
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139589B2

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