Water → (E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonic acid

HRID 2283261노트

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HRID 2283261 반응식
Br[C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[S:10]([O:13]CC)(=[O:12])=[O:11])=[CH:4][CH:3]=1.[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[C:17]1B(O)O.C(=O)([O-])[O-].[Na+].[Na+].O>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[O:16]1[C:17]2=[CH:18][CH:19]=[CH:24][C:23]2=[CH:22][CH:21]=[C:20]1[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][C:5]=1/[CH:8]=[CH:9]/[S:10]([OH:13])(=[O:11])=[O:12]

참가 물질

7

반응물 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2776266Benzo[b]furan-2-boronic acidHCID 866320021-Bromo-4-[(E)-2-ethoxysulfonylethenyl]benzene

생성물 1

HCID 86632001(E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonic acid

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 6228Dimethylformamide용매

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온도
90 °C

실험 절차

1-Bromo-4-[(E)-2-ethoxysulfonylethenyl]benzene (1.0 g, 3.4 mmol) and benzofuran-2-boronic acid (0.61 g, 3.7 mmol) were dissolved in DMF (20 mL). Sodium carbonate (2M, 10 mL) and tetrakis(triphenylphosphine)palladium(0) (200 mg, 0.17 mmol) were added and the resulting mixture was stirred under argon at 90° C. for 12 h. Water was added to the mixture and the resulting precipitate was collected, washed with water and dried to give the product as a sodium salt which was used in the next step without further purification (0.38 g, 35%).

후처리

  1. customthe resulting precipitate was collected
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-6f7934a3cfb64b659960316d4ee6f006
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145380B2

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