2-Aminobenzenesulfonamide → HCID 57750902, 화합물

HRID 2283292노트

반응식

HRID 2283292 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](=[O:9])(=[O:10])[NH2:11])(=[O:22])=[O:21]

참가 물질

4

반응물 2

HCID 728942-AminobenzenesulfonamideHCID 218690652,3-Difluorobenzene-1-sulfonyl chloride

생성물 1

HCID 57750902HCID 57750902, 화합물수율 58%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Aminobenzenesulfonamide (26 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (30 mg, 58%).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

출처 및 근거

ORD 기록
ord-9548669f86c64afbbc317c705e043bf3
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145380B2

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