2,3-Difluorobenzene-1-sulfonyl chloride → HCID 57751038, 화합물

HRID 2283293노트

반응식

HRID 2283293 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>N1C=CC=CC=1>[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH2:12])(=[O:23])=[O:22]

참가 물질

4

반응물 2

HCID 218690652,3-Difluorobenzene-1-sulfonyl chlorideHCID 224818252-Amino-5-fluorobenzenesulfonamide

생성물 1

HCID 57751038HCID 57751038, 화합물수율 46%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Amino-5-fluorobenzenesulfonamide (29 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (25 mg, 46%).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

출처 및 근거

ORD 기록
ord-90068a253ac7493f8ac7190cdebc4c47
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145380B2

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