2,3-Dichlorobenzene-1-sulfonyl chloride → 2,3-Dichloro-N-(3,5-difluoro-2-sulfamoylphenyl)benzenesulfonamide

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[S:22]([NH:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[S:10](=[O:12])(=[O:11])[NH2:13])(=[O:24])=[O:23]

참가 물질

반응물 2

HCID 27342222,3-Dichlorobenzene-1-sulfonyl chloride

HCID 231042292-Amino-4,6-difluorobenzenesulfonamide

생성물 1

HCID 577511052,3-Dichloro-N-(3,5-difluoro-2-sulfamoylphenyl)benzenesulfonamide수율 7%

실험 절차

The title compound was synthesized as described for Example 194 a) in 7% yield, starting from 2-amino-4,6-difluorobenzenesulfonamide and 2,3-dichlorobenzene-1-sulfonyl chloride (1.5 equiv.). Purification by preparative HPLC.

후처리

customPurification by preparative HPLC

출처 및 근거

ORD 기록: ord-7cb954e6d69b41f1b1d7b1008c572e6a
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09145380B2

반응 노트

불러오는 중…