Sodium Sulfite → Sodium 2-(4-bromo-phenyl)-ethanesulfonate

HRID 2283355노트

반응식

HRID 2283355 반응식
[S:1]([O-:4])([O-:3])=[O:2].[Na+:5].[Na+].[Br:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15]Br)=[CH:10][CH:9]=1>O>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][S:1]([O-:4])(=[O:3])=[O:2])=[CH:10][CH:9]=1.[Na+:5]

참가 물질

4

반응물 2

HCID 24437Sodium SulfiteHCID 110108254-Bromophenethyl bromide

생성물 1

HCID 57751107Sodium 2-(4-bromo-phenyl)-ethanesulfonate수율 86%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
106 °C

실험 절차

Sodium sulfite (4.75 g, 37.68 mmol) was added to a suspension of 1-bromo-4-(2-bromo-ethyl)-benzene (5.00 g, 18.94 mmol) in water (60 mL). The reaction mixture was heated at 105-107° C. for 18 hours and then cooled to −5° C. The formed precipitate was removed by filtration, washed with water (50 mL) and dried under vacuum to give 4.33 g (86% yield) of the title compound.

후처리

  1. temperaturecooled to −5° C
  2. customThe formed precipitate was removed by filtration
  3. washwashed with water (50 mL)
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-92c045bf23354eadae686d9deb7dab86
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145380B2

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