Water → HCID 89544754, 화합물

HRID 2283390노트

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HRID 2283390 반응식
[Cl:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[C:6]([F:16])[C:5]([CH:17](Br)Br)=[CH:4][CH:3]=1.C([OH:23])(C)C.O>[N+]([O-])([O-])=O.[Ag+].ClCCl>[C:8]([C:7]1[C:6]([F:16])=[C:5]([CH:4]=[CH:3][C:2]=1[Cl:1])[CH:17]=[O:23])(=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 3776IsopropanolHCID 89544515HCID 89544515, 화합물

생성물 1

HCID 89544754HCID 89544754, 화합물수율 90%

시약·촉매·용매 2

HCID 24470Silver Nitrate촉매HCID 6344Dichloromethane용매

실험 절차

Step 4 A mixture of (6-chloro-3-dibromomethyl-2-fluoro-phenyl)-phenyl-methanone (582 mg, 1.38 mmol), silver nitrate (469 mg, 2.76 mmol), isopropanol (10 ml) and water (2 ml) was stirred at room temperature overnight. Dichloromethane was added and the mixture was filtered under suction washing with isopropanol. The organic liquors were concentrated then purified by silica chromatography eluting with 0-20% ethyl acetate/petroleum ether furnishing 3-benzoyl-4-chloro-2-fluoro-benzaldehyde (222 mg oil, 90% clean). Analytical data as above

후처리

  1. filtrationthe mixture was filtered under suction
  2. washwashing with isopropanol
  3. concentrationThe organic liquors were concentrated
  4. customthen purified by silica chromatography
  5. washeluting with 0-20% ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-7fa7af75ac5d4723aaa094068a7416e3
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145354B2

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