(5,6-Dichloropyridin-3-yl)methanol → 5,6-Dichloropyridine-3-carbaldehyde

HRID 228347노트

반응식

HRID 228347 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1[Cl:8]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[O:10])[CH:5]=[N:6][C:7]=1[Cl:8]

참가 물질

4

반응물 1

HCID 21882961(5,6-Dichloropyridin-3-yl)methanol

생성물 1

HCID 115356545,6-Dichloropyridine-3-carbaldehyde수율 48%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

Combine (5,6-dichloro-pyridin-3-yl)-methanol (3.05 g, 17.11 mmol) and manganese dioxide (37.2 g, 427.9 mmol) in CH2Cl2 (25 mL). Stir the reaction mixture at rt overnight. Filter the reaction mixture through Celite® washing with CH2Cl2 (2×10 mL). Concentrate the filtrate and dry under vacuum to provide the title compound (1.44 g, 48%).

후처리

  1. filtrationFilter the reaction mixture through Celite®
  2. washwashing with CH2Cl2 (2×10 mL)
  3. concentrationConcentrate the filtrate
  4. customdry under vacuum

출처 및 근거

ORD 기록
ord-e81bbb2809cb4846bb6df3889b0f11a6
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560463B2

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