5-Fluoro-2-nitroanisole → (3-methoxy-4-nitrophenyl)(methyl)sulfane(WX191877)

HRID 2283508노트

반응식

HRID 2283508 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][S-:14].[Na+]>CN(C=O)C.O>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([S:14][CH3:13])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 2

HCID 27792505-Fluoro-2-nitroanisoleHCID 4378561Sodium methanethiolate

생성물 1

HCID 86688022(3-methoxy-4-nitrophenyl)(methyl)sulfane(WX191877)수율 59.2%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-fluoro-2-methoxy-1-nitrobenzene (1.38 g, 8.06 mmol) and sodium methyl mercaptide (0.622 g, 8.87 mmol) in DMF (25 mL) was stirred at room temperature for 18 hours. The reaction was the diluted with water and extracted with EtOAc. The combined extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to give (3-methoxy-4-nitrophenyl)(methyl)sulfane (0.95 g, 59%).

후처리

  1. extractionextracted with EtOAc
  2. washThe combined extracts were washed with brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-86ecef930b4c4432b501cd96b42cc925
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145402B2

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