Water → 3-Bromo-4-(5-formyl-pyridin-2-yloxy)-benzonitrile

HRID 228353

반응식

HRID 228353 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1.[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[OH:19])[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+].O>CC(N(C)C)=O>[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[O:19][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[O:9])=[CH:6][N:7]=1)[C:14]#[N:15]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 753413-Bromo-4-hydroxybenzonitrileHCID 27640536-Chloropyridine-3-carbaldehyde

생성물 1

HCID 597299663-Bromo-4-(5-formyl-pyridin-2-yloxy)-benzonitrile수율 72.1%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

Combine 6-chloro-pyridine-3-carbaldehyde (1.00 g, 7.09 mmol), 3-bromo-4-hydroxy-benzonitrile (1.48 g, 7.80 mmol) in dimethylacetamide (40 mL). Add potassium carbonate (1.47 g, 10.64 mmol) and stir and heat the reaction at 130° C. for 2 h. Let cool down the reaction to room temperature and poured into water. Filter the precipitate formed, washing with water, to give the title compound (1.55 g, 72%)

후처리

  1. temperatureheat
  2. customthe reaction at 130° C. for 2 h
  3. filtrationFilter the precipitate
  4. customformed
  5. washwashing with water

출처 및 근거

ORD 기록
ord-f4ef084bfb504cd3a66578589b4f684e
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560463B2

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