Boron tribromide → 2-Hydroxy-5-(trifluoromethoxy)phenylboronic acid

HRID 2283639노트

반응식

HRID 2283639 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:5][C:4]=1[B:14]([OH:16])[OH:15].B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:11])[F:12])=[CH:5][C:4]=1[B:14]([OH:16])[OH:15]

참가 물질

4

반응물 2

HCID 25134Boron tribromide2회HCID 222491602-Methoxy-5-(trifluoromethoxy)phenylboronic acid

생성물 1

HCID 666556152-Hydroxy-5-(trifluoromethoxy)phenylboronic acid수율 96.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

A suspension of 2-methoxy-5-(trifluoromethoxy)phenylboronic acid (23.0 g, 97.5 mmol) in dichloromethane (140 mL) was cooled to 0° C. and boron tribromide (9.4 mL, 10 mmol) was added drop-wise over 30 min. After stirring for 3 hours, additional boron tribromide (2 mL) was added. The reaction mixture was poured into ice water and stirred for 20 min. The dichloromethane was removed in vacuo and the white solid collected by filtration and washed with water before drying in vacuo to afford the title compound (20.8 g).

후처리

  1. stirringstirred for 20 min
  2. customThe dichloromethane was removed in vacuo
  3. filtrationthe white solid collected by filtration
  4. washwashed with water
  5. custombefore drying in vacuo

출처 및 근거

ORD 기록
ord-595b9cc25da649e1960bdf82ccb64975
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145407B2

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