7-bromo-5-nitro-1H-indazole → HCID 90308679, 화합물
반응식
F[B-](F)(F)F.[CH3:6][O+](C)C.[Br:10][C:11]1[CH:12]=[C:13]([N+:20]([O-:22])=[O:21])[CH:14]=[C:15]2[C:19]=1[NH:18][N:17]=[CH:16]2>C(OCC)(=O)C>[Br:10][C:11]1[C:19]2[C:15](=[CH:16][N:17]([CH3:6])[N:18]=2)[CH:14]=[C:13]([N+:20]([O-:22])=[O:21])[CH:12]=1참가 물질
4
실험 절차
Trimethyloxonium tetrafluoroborate (1.5 g) was added to a solution of 7-bromo-5-nitro-1H-indazole (1.21 g) in ethyl acetate (12 mL), and the reaction solution was stirred at room temperature for 6 hours. After dilution with ethyl acetate, the reaction solution was washed successively with water and a saturated saline solution and then dried over anhydrous sodium sulfate. The solvent was evaporated under vacuum, ethyl acetate and isopropyl ether were added to the resultant residue, and the deposited precipitate was filtrated to obtain 7-bromo-2-methyl-5-nitro-2H-indazole as a light yellow solid.