Potassium Carbonate → di(tert-butyl) 1-(4-hydroxybutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate
반응식
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]([CH2:43][CH2:44][CH3:45])[N:17]=[C:18]2[C:27]=1[C:26]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:20]=[C:19]2[N:28]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])(=O)C>CO>[OH:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]([CH2:43][CH2:44][CH3:45])[N:17]=[C:18]2[C:27]=1[C:26]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:20]=[C:19]2[N:28]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]참가 물질
4
실험 절차
Potassium carbonate (6 mg, 0.041 mmol) was added to a solution of 4-{4-[bis(tert-butoxycarbonyl)amino]-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl}butyl acetate (0.8823 g, 1.632 mmol) in methanol (5 mL). The mixture was stirred at ambient temperature for 1.3 hours. The volatiles were removed under reduced pressure. The resulting oil was purified by flash chromatography (silica gel, eluted with 100% ethyl acetate) to yield 0.1466 g of di(tert-butyl) 1-(4-hydroxybutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate in about 87% purity.