Einecs 211-027-4 → HCID 66958727, 화합물

HRID 2283835노트

반응식

HRID 2283835 반응식
[CH2:1]([N:3]1[C:15]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:14]2[C:5]([C:6]([NH2:26])=[N:7][C:8]3[CH:9]=[C:10]([O:24]C)[CH:11]=[CH:12][C:13]=32)=[N:4]1)[CH3:2].[Cl-:27].[NH+]1C=CC=CC=1>>[ClH:27].[NH2:26][C:6]1[C:5]2=[N:4][N:3]([CH2:1][CH3:2])[C:15]([CH2:16][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[C:14]2[C:13]2[CH:12]=[CH:11][C:10]([OH:24])=[CH:9][C:8]=2[N:7]=1

참가 물질

3

반응물 2

HCID 69401Einecs 211-027-4HCID 57717501HCID 57717501, 화합물

생성물 1

HCID 66958727HCID 66958727, 화합물수율 96.3%

실험 절차

2-Ethyl-7-methoxy-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-4-amine (0.37 g, 1.07 mmol) was added in one portion to boiling pyridinium chloride (3.70 g, 32.0 mmol). The mixture was heated at reflux for 4 hours, and then was allowed to cool to room temperature. The mixture was triturated with ice water and the precipitate was isolated by filtration, washed with water, and dried to yield 0.38 g of 4-amino-2-ethyl-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-7-ol hydrochloride as a light grey solid, mp>300° C.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe mixture was triturated with ice water
  4. customthe precipitate was isolated by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-18db397a2f9744bb86d9870fd5abc3ab
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145410B2

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