4,4'-Diaminobenzophenone → N,N'-(carbonylbis(4,1-phenylene))bis(4-(4-hydroxypiperidin-1-yl)benzamide)

반응식

[NH2:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[OH:17][CH:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:32]=[CH:31][C:27]([C:28]([O-])=[O:29])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1>>[C:6]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([N:21]3[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]3)=[CH:25][CH:26]=2)=[CH:10][CH:9]=1)([C:5]1[CH:15]=[CH:16][C:2]([NH:1][C:28](=[O:29])[C:27]2[CH:26]=[CH:25][C:24]([N:21]3[CH2:22][CH2:23][CH:18]([OH:17])[CH2:19][CH2:20]3)=[CH:32][CH:31]=2)=[CH:3][CH:4]=1)=[O:7]

참가 물질

반응물 2

HCID 691494,4'-Diaminobenzophenone

HCID 286044354-(4-Hydroxypiperidino)benzoate

생성물 1

HCID 67113077N,N'-(carbonylbis(4,1-phenylene))bis(4-(4-hydroxypiperidin-1-yl)benzamide)

실험 절차

Compound 323 was prepared according to the procedure described in Scheme IV from 4,4′-diaminobenzophenone and 4-(4-hydroxypiperidino)benzoate. [M+H]+ calcd for C37H39N4O5: 619.29; found: 619.10.

출처 및 근거

ORD 기록: ord-5f44405d8ef942c39814f26f80b1aef3
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09144557B2

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