Triethylamine → HCID 12928961, 화합물

HRID 2285604노트

반응식

HRID 2285604 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 788644-ChloroquinazolineHCID 235127975-Phenoxypentylamine

생성물 1

HCID 12928961HCID 12928961, 화합물수율 19.5%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution of 1.7 g (0.01 mol) of 4-chloroquinazoline in 50 ml of benzene were added 1.0 g (0.01 mol) of triethylamine and 1.8 g (0.01 mol) of 5-phenoxypentylamine, and the mixture was refluxed for 3 hours. After completion of the reaction, the benzene was evaporated under reduced pressure to leave crystals, which were washed with water, collected by filtration and recrystallized from aqueous ethanol, giving 0.6 g of 4-(5-phenoxypentyl)aminoquinazoline in the form of colorless flakes.

후처리

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter completion of the reaction
  3. customthe benzene was evaporated under reduced pressure
  4. customto leave crystals, which
  5. washwere washed with water
  6. filtrationcollected by filtration
  7. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-b1a21cd233064625b12b877b47a67c12
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04323680

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