2,6-Pyridinedimethanamine → HCID 70545036, 화합물

HRID 2285711노트

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HRID 2285711 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]C1C=C(Cl)C(Cl)=CC=1Cl)=O.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH2:29])[N:23]=1>CN(C)C=O>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][C:8](=[O:10])[CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[N:23]=1)=[O:10]

참가 물질

4

반응물 2

HCID 137237542,6-PyridinedimethanamineHCID 20544060HCID 20544060, 화합물

생성물 1

HCID 70545036HCID 70545036, 화합물수율 57%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

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온도
60 °C

실험 절차

0.02 mol of 2,4,5-trichlorophenyl 2-oxo-pyrrolidineacetate is dissolved in 50 ml of dimethylformamide and reacted with a solution of 0.01 mol of 2,6-diaminomethylpyridine in 20 ml of dimethylformamide, at -5° C., whilst stirring and with the exclusion of moisture. After leaving the reaction solution to stand at room temperature for three hours, it is warmed to 60° C. for 2 hours, the solvent is then evaporated off, ether is added to the residue and the crystals which precipitate are filtered off. Melting point: 149° C., yield 57% of theory

후처리

  1. customAfter leaving the reaction solution
  2. customthe solvent is then evaporated off
  3. additionether is added to the residue
  4. filtrationthe crystals which precipitate are filtered off

출처 및 근거

ORD 기록
ord-50e5dd8310a0402e81334b983cd7ea69
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04324787

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