Water → (4-Hydroxyphenyl)(3-methylphenyl)methanone

HRID 228601

반응식

HRID 228601 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=2)=[O:10])=[CH:5][CH:4]=1.B(Br)(Br)Br.ClCCl.O>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=2)=[O:10])=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 12469466(4-Methoxyphenyl)(3-methylphenyl)methanoneHCID 22277759Boron tribromide dichloromethane

생성물 1

HCID 22132621(4-Hydroxyphenyl)(3-methylphenyl)methanone수율 265.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(4-Methoxyphenyl)(3-methylphenyl)methanone (603 mg) was dissolved in dichloromethane (3 ml) to prepare a solution. A boron tribromide-dichloromethane solution (1.0 M) (11 ml) was added to the solution, and the mixture was stirred at room temperature for 2 days. The reaction solution was poured into ice-cooled water, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, was dried over sodium sulfate, and was then concentrated. The residue was subjected to separation and purification by column chromatography on silica gel using hexane/ethyl acetate as a solvent to give (4-hydroxyphenyl)(3-methylphenyl)methanone (1.50 g, yield 56%).

후처리

  1. customto prepare a solution
  2. additionThe reaction solution was poured into ice-
  3. extractionthe mixture was extracted with chloroform
  4. washThe organic layer was washed with saturated brine
  5. dry with materialwas dried over sodium sulfate
  6. concentrationwas then concentrated
  7. customThe residue was subjected to separation and purification by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-32e8ef05d2084566b2a7db68dcf6d5f0
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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