N,N-Dimethyl-1,3-propanediamine → N-(3'-Dimethylaminopropyl)-aspartic acid-4-cyclohexyl ester

HRID 2286015

반응식

HRID 2286015 반응식
[CH:1]1([O:7][C:8](=[O:14])/[CH:9]=[CH:10]\[C:11]([OH:13])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19][NH2:20]>C(N(CC)CC)C>[CH2:4]1[CH2:3][CH2:2][CH:1]([O:7][C:8](=[O:14])[C@H:9]([CH2:10][C:11]([OH:13])=[O:12])[NH:20][CH2:19][CH2:18][CH2:17][N:16]([CH3:21])[CH3:15])[CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 69130071-Cyclohexyl (2Z)-2-butenedioate

생성물 1

HCID 86738345N-(3'-Dimethylaminopropyl)-aspartic acid-4-cyclohexyl ester수율 73.2%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

In a manner analogous to that described in Example 1, 100 ml of triethylamine are added dropwise, with cooling, to 99.1 g (0.5 mol) of maleic acid-monocyclohexyl ester, and the mixture is reacted with 61.3 g (0.5 mol+20% excess) of 3-dimethylaminopropylamine for 1 hour at 80°-93° C. The reaction product is purified as described in Example 1 to yield 109.9 g (73.2% of theory) of the desired aspartic acid derivative having a melting point of 150°-152.5° C.

후처리

  1. additionare added dropwise
  2. customThe reaction product is purified

출처 및 근거

ORD 기록
ord-ce5aed9be49442b2a92ce4197b18d601
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04326069

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