5-(Hydroxymethyl)pyrrolidin-2-one → 6-Oxo-piperidine-2-carbaldehyde

반응식

[OH:1][CH2:2][CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.OCC1NC(=O)CC1>>[CH:2]([CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1)=[O:1]

참가 물질

반응물 2

HCID 5583595-(Hydroxymethyl)pyrrolidin-2-one

HCID 145063136-(Hydroxymethyl)piperidin-2-one

생성물 1

HCID 199030706-Oxo-piperidine-2-carbaldehyde

실험 절차

When in the procedure of Example 6 (A) an appropriate amount of 6-hydroxymethyl-2-piperidone is substituted for 5-hydroxymethyl-2-pyrrolidone, 6-formyl-2-piperidone is obtained. When an appropriate amount of 6-formyl-2-piperidone is substituted for 5-formyl-2-pyrrolidone in the procedure of Example 6 (B), 6-difluoromethyl-2-piperidone is obtained which, when substituted for 5-difluoromethyl-2-pyrrolidone in an appropriate amount in the procedure of Example 5, yields 5-amino-5-difluoromethylpentanoic acid.

출처 및 근거

ORD 기록: ord-fd32177042dd40cb93dfc3c6295309c8
출처 데이터셋: uspto-grants-1982_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04326071

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