Ethanol → HCID 53893301, 화합물

HRID 2286119노트

반응식

HRID 2286119 반응식
[NH2:1][CH:2]([CH:8]([F:10])[F:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].S(Cl)(Cl)=O.[CH2:15](O)[CH3:16]>ClCCl>[CH2:15]([O:6][C:5](=[O:7])[CH2:4][CH2:3][CH:2]([NH2:1])[CH:8]([F:10])[F:9])[CH3:16]

참가 물질

5

반응물 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 13050369HCID 13050369, 화합물

생성물 1

HCID 53893301HCID 53893301, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

A solution of 2 mmole of 4-amino-4-difluoromethylbutyric acid in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour, washed with water, dried and concentrated to afford 4-amino-4-difluoromethylbutyric acid ethyl ester.

후처리

  1. additionis added
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-05eaa20eb3ff4d02972b21dba56209c7
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04326071

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