2-Cyclohexen-1-one, 3,5-dimethyl-4-(3-methyl-2-buten-1-yl)- → 3,5-Dimethyl-4-(3-methyl-2-butenyl) cyclohexanone

HRID 2286141노트

반응식

HRID 2286141 반응식
[CH3:1][C:2]1[CH:7]([CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])[CH:6]([CH3:13])[CH2:5][C:4](=[O:14])[CH:3]=1.[H][H]>[OH-].[K+].[Pd]>[CH3:1][CH:2]1[CH:7]([CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])[CH:6]([CH3:13])[CH2:5][C:4](=[O:14])[CH2:3]1

참가 물질

5

반응물 2

HCID 936962-Cyclohexen-1-one, 3,5-dimethyl-4-(3-methyl-2-buten-1-yl)-HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 204692633,5-Dimethyl-4-(3-methyl-2-butenyl) cyclohexanone수율 87.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 14797Potassium Hydroxide용매

실험 절차

A solution of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one (8.2 g, 0.043 mol) in 0.3 M ethanolic KOH (16 mL) was hydrogenated at room temperature and 1 atmosphere over 5% palladium on carbon (0.8 g). After uptake of 1 equivalent of hydrogen, the solution was filtered through Celite and concentrated. The residue was partitioned between hexane and water; then the hexane layer was dried (Na2SO4) and the solvent removed on a rotary evaporator. Kugelrohr distillation gave 7.3 g of 3,5-dimethyl-4-(3-methyl-2-butenyl) cyclohexanone, bp 115° C./0.5 mm.

후처리

  1. customwas hydrogenated at room temperature
  2. concentrationconcentrated
  3. customThe residue was partitioned between hexane and water
  4. dry with materialthen the hexane layer was dried (Na2SO4)
  5. customthe solvent removed on a rotary evaporator
  6. distillationKugelrohr distillation

출처 및 근거

ORD 기록
ord-90c556e4443d4828b49119ceb5ec21c7
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04326996

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