(Pyrazin-2-yl)acetonitrile → HCID 136359207, 화합물

HRID 2286259노트

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HRID 2286259 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].[N:10]([O-])=[O:11].[Na+]>C(O)(=O)C>[OH:11][N:10]=[C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)[C:8]#[N:9]

참가 물질

4

반응물 2

HCID 12782906(Pyrazin-2-yl)acetonitrileHCID 23668193Sodium Nitrite

생성물 1

HCID 136359207HCID 136359207, 화합물수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Pyrazineacetonitrile (32 g), prepared as described in British Patent Specification No. 1 021 397, was dissolved in glacial acetic acid (250 ml). The solution was stirred and 1.2 equivalents of sodium nitrite (22.3 g) were added in small portions, while the temperature was kept under 20° C. After the addition, the reaction mixture was stirred at room temperature for another two hours. The title compound separated partly from the reaction mixture. On evaporation of the solvent under reduced pressure, a solid was obtained which on recrystallization from hot water yielded α-hydroxyiminopyrazineacetonitrile (35 g, 88%). Melting point >192° C. (dec.).

후처리

  1. customwas kept under 20° C
  2. additionAfter the addition
  3. stirringthe reaction mixture was stirred at room temperature for another two hours
  4. customThe title compound separated partly from the reaction mixture
  5. customOn evaporation of the solvent under reduced pressure
  6. customa solid was obtained which
  7. customon recrystallization from hot water

출처 및 근거

ORD 기록
ord-ba42fb78d84b4530927d9718759347b2
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04327213

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