참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Iodo-6-methylpyridin-3-ol | HCID 89957 | — |
| 반응물 | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 4-[(6-Methyl-3-pyridyl)oxy]-6,7-dimethoxyquinoline | HCID 23156628 | 61.3% |
반응 단계
4-Chloro-6,7-dimethoxyquinoline (229 mg), 3-hydroxy-2-iodo-6-methylpyridine (486 mg), and 4-dimethylaminopyridine (390 mg) were suspended in o-dichlorobenzene (5 ml), and the suspension was stirred at 140° C. overnight. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-chloroform to give the title compound (186 mg, yield 61%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07560558B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-34b0655ea6c04a9ea66bcd791d15dedf |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
