참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| 반응물 | 3-Hydroxy-6-methylpyridine-2-carbaldehyde | HCID 12421986 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 6-Methyl-2-pyridinecarboxaldehyde | HCID 70737 | 13.6% |
반응 단계
4-Chloro-6,7-dimethoxyquinoline (330 mg), 3-hydroxy-6-methyl-2-pyridinecarbaldehyde (200 mg), and 4-dimethylaminopyridine (360 mg) were suspended in o-dichlorobenzene (7 ml), and the suspension was stirred at 150° C. for 3 hr. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-chloroform to give 3-[6,7-dimethoxy-4-quinolyl]oxy}-6-methyl-2-pyridinecarbaldehyde (24 mg, yield 5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07560558B2 |
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| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-4db4ba8d7bab46529eeeeb2c47d6995c |
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| 출처 메모 | uspto-grants-2009_07 |
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