Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → 1-(N-Methoxyacetylglycyl)-2-cyanoaziridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | Aziridine-2-carbonitrile | HCID 118115 | — |
| 반응물 | N-(Methoxyacetyl)glycine | HCID 16775934 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(N-Methoxyacetylglycyl)-2-cyanoaziridine | HCID 23461589 | — |
반응 단계
2.94 g. N-Methoxyacetylglycine are dissolved in 29 ml. tetrahydrofuran and mixed, with stirring and ice cooling, with 1.36 g. 2-cyanoaziridine and 4.3 g. dicyclohexylcarbodiimide, whereafter the reaction mixture is stirred for 2 hours. After filtering off the dicyclohexylurea, from the filtrate there are obtained 2.8 g. of crystals which, for purification, are dissolved in ethyl acetate and reprecipitated with ligroin. There is thus obtained 1-(N-methoxyacetylglycyl)-2-cyanoaziridine; M.p. 70°-72° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04267174 |
| 출처 데이터셋 | uspto-grants-1981_05 |
| ORD ID | ord-67e7568198d34822ac72e76ba96baac0 |
| 출처 메모 | uspto-grants-1981_05 |