Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-tert-butyl 2-diphenylmethyl (2RS,3RS)-5-oxotetrahydrofuran-2,3-dicarboxylate → (2RS,3RS)-3-tert-butoxycarbonyl-5-oxotetrahydrofuran-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-tert-butyl 2-diphenylmethyl (2RS,3RS)-5-oxotetrahydrofuran-2,3-dicarboxylate | HCID 53807367 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (2RS,3RS)-3-tert-butoxycarbonyl-5-oxotetrahydrofuran-2-carboxylic acid | HCID 18705233 | 76.8% |
반응 단계
148 mg of 3-tert-butyl 2-diphenylmethyl (2RS,3RS)-5-oxotetrahydrofuran-2,3-dicarboxylate in 4 ml of ethyl acetate was catalytically reduced with 15 mg of a 10% palladium-carbon catalyst at room temperature at atmospheric pressure of hydrogen for 15 hours. The catalyst was filtered off, and the solvent was evaporated in vacuo. The residue was washed with benzene to give 66 mg of the title compound as a white crystalline powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06083985 |
| 출처 데이터셋 | uspto-grants-2000_07 |
| ORD ID | ord-6c243f1fbe8146a8b3bbede3a45e2142 |
| 출처 메모 | uspto-grants-2000_07 |