4-benzyloxy-1-ethyl-2-methyl-1H-benzimidazole → 1H-Benzimidazol-4-ol, 1-ethyl-2-methyl-
반응식
C([O:8][C:9]1[C:17]2[N:16]=[C:15]([CH3:18])[N:14]([CH2:19][CH3:20])[C:13]=2[CH:12]=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:19]([N:14]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([OH:8])[C:17]=2[N:16]=[C:15]1[CH3:18])[CH3:20]참가 물질
4
실험 절차
To a solution of 4-benzyloxy-1-ethyl-2-methyl-1H-benzimidazole (370 mg) in ethyl acetate (3.7 ml) was added 10% palladium on carbon (18 mg), and the mixture was stirred for 5 hours at ambient temperature under hydrogen atmosphere. Insoluble material was filtered off, and the filtrate was concentrated in vacuo. The residue was crystallized with diisopropyl ether to give 1-ethyl-4-hydroxy-2-methyl-1H-benzimidazole (220 mg)
후처리
- filtrationInsoluble material was filtered off
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was crystallized with diisopropyl ether
출처 및 근거
- ORD 기록
- ord-75085759b9264bcbbe53595289868beb
- 출처 데이터셋
- uspto-grants-2000_07
- 특허 번호
- US06083961
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