Malonic Acid → 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid

HRID 2287592노트

반응식

HRID 2287592 반응식
[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.C(O)(=O)[CH2:18][C:19]([OH:21])=[O:20].C(OCC)(=O)C>N1C=CC=CC=1.C(O)C>[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:18][C:19]([OH:21])=[O:20])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 867Malonic AcidHCID 8857Ethyl AcetateHCID 53747304-(2-(4-Formylphenyl)ethenyl)pyridine

생성물 1

HCID 702455054-[(E)-2-(4-pyridyl)vinyl]cinnamic acid수율 46.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1049Pyridine용매

실험 절차

To a solution of 4-[(E)-2-(4-pyridyl)vinyl]benzaldehyde (50 mg) in pyridine (0.025 ml) and ethanol (0.075 ml) was added malonic acid (27.4 mg), and the mixture was refluxed for 7 hours. After cooling, ethyl acetate was added thereto, the resulting precipitates were collected by filtration to give 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid (28 mg).

후처리

  1. temperaturethe mixture was refluxed for 7 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-1bfb60053e6c41a9995cfa13720026b7
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06083961

반응 노트

불러오는 중…