참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Nitroaniline | HCID 7423 | — |
| 반응물 | 7-Amino-4-methylthiopyrido[4,3-d]pyrimidine | HCID 10442562 | — |
| 생성물 | 7-Amino-4-(3-nitroanilino)pyrido[4,3-d]pyrimidine | HCID 5328053 | 43.5% |
반응 단계
A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (127 mg, 0.66 mmol) (described in a previous experimental) and 3-nitroaniline (1.70 g, 12.3 mmol) is stirred under N2 at 200° C. for 1.5 h. The resulting product is chromatographed over alumina (5-20% EtOH/CHCl3) to give 7-amino-4-(3-nitroanilino)pyrido[4,3-d]pyrimidine (81 mg, 39%) as a brown solid. 1H NMR (DMSO) δ 10.17 (1H, brs), 9.37 (1H, s), 8.87 (1H, brs), 8.48 (1H, s), 8.33 (1H, brd, J=7.5 Hz), 7.95 (1H, ddd, J=8.2, 2.1, 1.0 Hz), 7.67 (1H, t, J=8.2 Hz), 6.70 (2H, brs), 6.47 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06084095 |
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| 출처 데이터셋 | uspto-grants-2000_07 |
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| ORD ID | ord-635ea70271ac4b93809a72793dd53823 |
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| 출처 메모 | uspto-grants-2000_07 |
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