참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Iodoaniline | HCID 12271 | — |
| 반응물 | 7-Amino-4-methylthiopyrido[4,3-d]pyrimidine | HCID 10442562 | — |
| 생성물 | 4-N-(3-iodophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine | HCID 5328071 | 61.8% |
반응 단계
A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (72 mg, 0.37 mmol) and 3-iodoaniline (1.25 g, 5.71 mmol) is stirred at 160° C. for 30 min. The resulting product is chromatographed over silica gel (5-7% MeOH/CH2Cl2) to give 7-amino-4-(3-iodoanilino)pyrido[4,3-d]pyrimidine (83 mg, 61%) as a light brown rosettes. 1H NMR (DMSO) δ 9.84 (1H, brs), 9.34 (1H, s), 8.44 (1H, s), 8.30 (1H, brs), 7.90 (1H, dd, J=7.9, 0.8 Hz), 7.47 (1H, d, J=7.7 Hz), 7.18 (1H, t, J=8.0 Hz), 6.66 (2H, brs), 6.46 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06084095 |
|---|
| 출처 데이터셋 | uspto-grants-2000_07 |
|---|
| ORD ID | ord-bd0b2aa1003f48ebbcd883c7806aa218 |
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| 출처 메모 | uspto-grants-2000_07 |
|---|
