Ethanolamine → 6-(2-Hydroxyethyl-aminocarbonyl)-2-naphthoic acid

HRID 2287946

반응식

HRID 2287946 반응식
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=2)[CH:6]=1)=[O:4].[CH2:18]([CH2:20][NH2:21])[OH:19]>>[OH:19][CH2:18][CH2:20][NH:21][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([OH:17])=[O:16])[CH:9]=[CH:8]2)=[O:4]

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 33802176-(Methoxycarbonyl)naphthalene-2-carboxylic acid

생성물 1

HCID 187029066-(2-Hydroxyethyl-aminocarbonyl)-2-naphthoic acid

실험 절차

2.1 g of naphthalene-2,6-dicarboxylic acid monomethyl ester and 25 ml of ethanolamine are heated at 150° C. for 3 h. The excess ethanolamine is distilled off in vacuo, and the residue is dissolved in water and the mixture is extracted with ethyl acetate. After acidifying the aqueous phase, the product which is deposited is filtered off with suction and recrystallized from ethanol. 1.2 g of 6-(2-hydroxyethyl-aminocarbonyl)-2-naphthoic acid are obtained.

후처리

  1. distillationThe excess ethanolamine is distilled off in vacuo
  2. dissolutionthe residue is dissolved in water
  3. extractionthe mixture is extracted with ethyl acetate
  4. filtrationthe product which is deposited is filtered off with suction
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7f7238c97ffa4653a3967569cb05ce1a
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06087304

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