Ammonia → 5,6-Dimethyl-2-pyridin-2-yl-pyridin-3-ol

HRID 228812

반응식

HRID 228812 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:16]>CO>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[N:16][C:6]=1[CH3:7]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 23078484(4,5-Dimethylfuran-2-yl)-(2-pyridyl)-methanone

생성물 1

HCID 1356000565,6-Dimethyl-2-pyridin-2-yl-pyridin-3-ol수율 75%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
160 °C

실험 절차

(4,5-Dimethylfuran-2-yl)-(2-pyridyl)-methanone (1.6 g), methanol (15 ml), and a 28% aqueous ammonia solution (15 ml) were placed in a sealed tube, and the mixture was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-[2,2′]-bipyridin-3-ol (1.2 g, yield 75%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-fcbb3681ca4446728a561ff7381997a1
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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