Ammonia → 5,6-Dimethyl-2-(6-methylpyridin-2-yl)pyridin-3-ol

HRID 228819

반응식

HRID 228819 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:17]>CO>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=[N:17][C:6]=1[CH3:7]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 23078390(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone

생성물 1

HCID 1363851075,6-Dimethyl-2-(6-methylpyridin-2-yl)pyridin-3-ol수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
160 °C

실험 절차

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (810 mg), methanol (7 ml), and a 28% aqueous ammonia solution (7 ml) were placed in a sealed tube, and the mixture was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,6′-trimethyl-[2,2′]bipyridin-3-ol (753 mg, yield 93%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-a944364cd8f04728b8ddcf3d402af187
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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