Ammonia → 5,6,5'-Trimethyl-[2,2']bipyridin-3-ol

HRID 228823노트

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HRID 228823 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12](C)[N:11]=2)=O)[O:5][C:6]=1[CH3:7].[NH3:17].[CH3:18]O>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:18])=[CH:12][N:11]=2)=[N:17][C:6]=1[CH3:7]

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 887MethanolHCID 23078390(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone

생성물 1

HCID 1363851085,6,5'-Trimethyl-[2,2']bipyridin-3-ol수율 68%

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온도
160 °C

실험 절차

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (780 mg), methanol (7 ml), and a 28% aqueous ammonia solution (7 ml) were placed in a sealed tube and were stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6,5′-trimethyl-[2,2′]bipyridin-3-ol (529 mg, yield 68%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-4bfe9740078f4312ab790b03d008545c
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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